By T. Haferlach, C. Schoch, W. Hiddemann (auth.), Prof. Dr. med. Wolfgang Hiddemann, Prof. Dr. Dr. med. phil. Torsten Haferlach, Dr. med. Michael Unterhalt, Prof. Dr. med. Thomas Büchner, Prof. Dr. med. Jörg Ritter (eds.)
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Extra info for Acute Leukemias IX: Basic Research, Experimental Approaches and Novel Therapies
In (A) the open boxes are regions of homology between ETO and the Drosophila homologue of ETO termed Nervy: TAFllO, a domain with homology to the Drosophila TAF 11 0 protein; HHR, hydrophobic heptad repeat; ND, nervy domain; ZF, zinc finger. HDAe, histone deacetylase. DBD, DNA binding domain. SMMHe, smooth muscle myosin heavy chain. 2. (A) Schematic diagram of the t(8;21) fusion protein and its molecular contacts with the N-CoR and mSin3 co-repressors and histone deacetylases. Open boxes are regions of homology with the Drosophila homologue of ETO termed Nervy.
In 50% of all cases being referred to the Reference Laboratory the diagnosis has been defined more exactly, namely T- or non-T-cell variants of ALL or one of AML variants (MI-M7) have been delineated on the basis of the analysis of cytochemical characteristics. When necessary immunological variant of ALL has been clarified according to the results of immunophenotyping. The distribution of the various variants of acute leukemias and non-Hodgkin's malignant lymphomas diagnosed in children examined in the Reference Laboratory in 1993-2001 is given in Table 2 and Table 3.
The immunomarker profile of the cell line is summarized in Table 1. The cells expressed typical B-cell associated markers on the membrane surface and intracytoplasmatically such as CD 10, CDI9, CD20, CD22, CD37, CD40, cyCD79a, and cyCD79b. As the cells were surface immunoglobulin (smlg)-negative, the cells can be classified as precursor B- Table 2. 3 x 106 cells/ml Minimum cell density ca. 2S x 106 cells/ml Optimal cell density ca. , megakaryocytic negative Progenitor/activation Cytokine receptors CD30+, CD34(+), CD38+, CD71+,HLA-DR+, Tdr+ CD119+ (IFN-yR), CDI27(+) (IL-7R), CD13S+ (FLT3) Genetic characterization: Cytogenetic karyotype 45<2n> X, - Y, t( 12;13)(p 12;q 13-14) Receptor gene rearrangement IGH RD, IGK GG Comments • Precursor B-celiline of type B-II (common B-cell line) • Uniqueness of cell line: carries t(12;13) cell line of type B-II (common B-cell line) according to the EGIL classification (Bene et al.