By Frederick W. Alt
Advances in Immunology, a protracted validated and hugely revered e-book, offers present advancements in addition to finished reports in immunology. Articles tackle the big variety of subject matters that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored via the major scientists within the box, each one quantity offers updated details and instructions for destiny examine.
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* hugely revered evaluate sequence with an impression think about 2003 of of 7.424 and ranked quantity 8/114
* New Editor, Frederick Alt
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Extra resources for Advances in Immunology, Volume 86
2007). Functional insights on the polarized redistribution of leukocyte integrins and their ligands during leukocyte migration and immune interactions. Immunological Reviews, 218, 147–164. Boateng, L. , & Huttenlocher, A. (2012). Spatiotemporal regulation of Src and its substrates at invadosomes. European Journal of Cell Biology, 91(11–12), 878–888. , & Welch, M. D. (2005). Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration.
M. (2013). Signaling inputs to invadopodia and podosomes. Journal of Cell Science, 126(Pt 14), 2979–2989. Jennings, R. , et al. (2014). RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness. Blood, 123(23), 3635–3645. , et al. (2001). Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. The Journal of Cell Biology, 153(5), 893–904. , et al. (2003). RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1.
Binding of ligands to integrin in turn triggers signaling cascades, called “outside-in signaling,” further regulating leukocyte behavior. , 1998). , 2007; Wittchen, Aghajanian, & Burridge, 2011). , 2002). In immune cells, Rap1 promotes lymphocyte adhesion and migration. , 2003). In addition, Rap1 recruits talin to the integrin β subunit tail, which is sufficient to open integrins into high ligand binding affinity. , 2009). These tensions further control lateral mobility of the integrin within the plasma membrane and play critical role in integrin clustering.