Allogeneic Stem Cell Transplantation (Current Clinical by Mary J. Laughlin, Hillard M. Lazarus

By Mary J. Laughlin, Hillard M. Lazarus

The world over well-known physicians and researchers overview either the fundamentals of allogeneic stem cellphone transplantation and up to date advances within the box, relatively as they relate to antitumor results and graft-versus-host sickness additionally they supply detailed decision-tree analyses to steer clinicians in picking and coping with their allogeneic transplant sufferers. The thoughts mentioned hide numerous parts, starting from stem mobile mobilization in general donors, to symptoms for allogeneic transplantation except hematologic malignancies, to using nonmyeloablative conditioning regimens. The authors additionally discover new advancements within the optimum number of unrelated allogeneic grafts (e.g., matched unrelated donor, partly mismatched friend, or umbilical twine blood), the use allogeneic peripheral blood stem mobile vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.

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Extra resources for Allogeneic Stem Cell Transplantation (Current Clinical Oncology)

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Patients between ages 40 and 50, and those under the age of 40 without a matched sibling donor, were further randomized to consolidation chemotherapy or autologous SCT using bone marrow purged with antibodies or mafosfamide. Consolidation chemotherapy consisted of three monthly courses of daunorubicin or zorubicin, Ara-C, and asparaginase followed by long-term maintenance therapy. The transplant preparative regimen consisted of total body irradiation (TBI) and cyclophosphamide. The 10-yr overall survival rate of patients greater than 50 yr treated with chemotherapy only was 27%.

These include in decreasing frequency, patients with t(9;22) (q34;q11), trisomy 8, t(4;11) (q21;q23), monosomy 7, a hypodiploid karyotype, and t(1;19) (5,6). The most common and clinically relevant cytogenetic abnormalities in adults with ALL include the t(9;22) (q34;q11) resulting in the BCR/ABL fusion gene that is present in as many as 30% of adult ALL patients, the t(4;11) (q21;q23) involving the MLL gene on chromosome 11q23 that results in the MLL/AF4 fusion gene, and the t(8;14) (q24;q32) chromosomal translocation seen in mature B lineage ALL (Burkitt’s type) that results in overexpression of the cMYC proto-oncogene.

63. Storb R, Yu C, McSweeney P. Mixed chimerism after transplantation of allogeneic hematopoietic cells. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoietic Cell Transplantation, 2nd ed. Blackwell Science, London, 1999, pp. 287–295. 64. Champlin R, Khouri I, Kornblau S, et al. Allogeneic hematopoietic transplantation as adoptive immunotherapy. In: Schiller GJ, guest ed. Hematology/Oncology Clinics of North America. B. Saunders, Phialdelphia, 1999, pp. 1041–1057. 65. McSweeney PA, Niederwieser D, Shizuru JA, et al.

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