Anemia in the Elderly by Lodovico Balducci, William B. Ershler, John M. Bennett

By Lodovico Balducci, William B. Ershler, John M. Bennett

Anemia within the aged has been appropriately outlined because the silent epidemic, representing three million humans within the usa elderly sixty five years and older. occurrence and occurrence of this situation raise with age. It differs in its etiology, pathogenesis and therapy from anemia in young children and more youthful adults. Anemia is linked to decreased survival, elevated hazard of practical dependence and hospitalization, elevated hazard of congestive center failure and level renal ailment and cognitive problems. nearly 70% of anemia in older members is reversible.

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A progressive decline in the digestion and absorption of nutrients due to reduced gastro-intestinal secretions, gastric motility, splanchnic circulation and absorbing surface. The absorption of iron, that my lead to iron deficiency may be hampered by hepcidine, a glycoprotein synthesized in the liver whose production is stimulated by IL-6 (13). The absorption of B12 may be reduced in older individuals due to inability to digest food bound cobalamaine; A number of endocrine changes, including decreased concentration of testosterone and dehydroepiandrotestosterone (DHEA), growth hormone, insulin, and thyroxine, while the concentration of corticosteroids in the circulation may be increased (14); Progressive reduction in marrow cellularity, associated with reduced ability to withstand hemopoietic stress (15).

2004;52:719–24 50. Penninx BW, Guralnik JM, Onder G et al: Anemia and decline in physical performance among older persons. Am J Med. 2003;115:104–10 51. Cesari M, Penninx BW, Lauretani F et al: Hemoglobin levels and skeletal muscle: results from the INCHIANTI study. J Gerontol A Biol Med Sci. 2004;59:238–41 52. Extermann M, Chen A, Cantor AB, Corcoran MB, Meyer J, Grendys E, Cavanaugh D, Antonek S, Camarata A, Haley WE, Balducci L: Predictors of tolerance from chemotherapy in older patients: a prospective pilot study.

Blood. 2006 May 15;107:3841–6 49. Penninx BW, Pahor M, Cesari M et al: Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc. 2004;52:719–24 50. Penninx BW, Guralnik JM, Onder G et al: Anemia and decline in physical performance among older persons. Am J Med. 2003;115:104–10 51. Cesari M, Penninx BW, Lauretani F et al: Hemoglobin levels and skeletal muscle: results from the INCHIANTI study. J Gerontol A Biol Med Sci. 2004;59:238–41 52.

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