Animal Hematotoxicology: A Practical Guide for Toxicologists by G.O. Evans

By G.O. Evans

Hematology info from in vivo toxicology experiences continues to be certainly one of  the main predictive measures for human chance, because the similar measurements made in pre-clinical toxicology experiences will be made in early medical trials.

Covering the 3 major blood mobilephone forms – erythrocytes, leukocytes and thrombocytes, this paintings is designed to explain subject matters for brand spanking new entrants to the fields of laboratory animal hematology and toxicology, particularly these subject matters the place the foundations for human hematology don't continuously observe. a complete bankruptcy is dedicated to immunotoxicology, a systematic self-discipline that's heavily aligned with hematology.

The textual content additionally addresses pre-analytical and analytical variables that have an effect on animal stories, as those play a much more very important half while analyzing info unlike people the place lots of those variables should be good managed or have much less physiological impression. info has been collated from released papers, textbooks and unpublished information: Readers are supplied with key references to inspire additional study

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Within the stroma there is a mixture of cells and binding proteins, including fibroblasts, adipocytes, fibronectin, proteoglycans, and macrophages. Bone marrow cellularity varies with stress (Moeller, 1991), site, and age, and it is subject to diurnal variation (Clark and Korst, 1969). , 1990; Matsumoto, 1991; Bollinger, 2004). For rats and mice, the femoral bone marrow is commonly used for examination; in dogs, bone marrow sample is usually taken from the iliac crest, sternum, or a rib, as the femoral marrow cavity has a high fatty content.

2001. Delineation among eight major hemopoietic subsets in murine bone marrow using a two-color cytometric technique. Cytometry 43:297–307. Smith, C. , Andrews, C. , Collard, J. , Hall, D. , and Walker, A. , eds. 1993. Color atlas of comparative diagnostic and experimental hematology. London: Wolfe Publishing, Mosby-Year Book Europe Ltd. Terstappen, L. W. M. , and Levin, J. 1992. Bone marrow cell differential counts obtained by multidimensional flow cytometry. Blood Cells 18:311–30. Valli, V. , Villeneuve, D.

Indb 22 6/24/08 5:26:44 AM 3 Erythrocytes, Anemias, and Polycythemias A simplified description of erythropoiesis is given in Chapter 2. In this chapter, some of the erythrocytic measurements and morphological comments, functions, and kinetics are discussed, followed by notes on various anemias and polycythemias. Preanalytical and analytical variables affecting erythrocytic measurements are discussed later in Chapters 9 and 10. The common abbreviations for red cell measurements are: Hb or Hgb HCT MCH MCHC MCV RBC Hemoglobin concentration Hematocrit (expressed as a decimal fraction or ratio); derived as HCT = RBC × MCV divided by 100; may also be measured by centrifugation as packed cell volume (PCV expressed as %) Mean corpuscular (or cell) hemoglobin; absolute hemoglobin concentration per erythrocyte; derived as MCH (pg) = Hb divided by RBC multiplied by 10 Mean cell hemoglobin concentration; relative quantity of Hb per erythrocyte; measured directly from the optical properties of the cell, or derived as MCHC (g/dl) = Hb divided by hematocrit Mean corpuscular (or cell) volume; measured directly or derived as HCT multiplied by 1000 divided by RBC Red blood cell count (erythrocyte) The calculations are based on SI units and the expression of hemoglobin concentration as g/dl (see Appendix D).

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