Antiangiogenic Agents in Cancer Therapy (Cancer Drug by Beverly A. Teicher

By Beverly A. Teicher

This quantity represents a compendium of clinical findings and methods to the examine of angiogenesis in melanoma. the second one variation of Antiangiogenic brokers in melanoma remedy is meant to provide a present viewpoint at the cutting-edge of angiogenensis and remedy directed at this strategy.

Antiangiogenesis is a dynamic and evolving box in oncology. New healing goals proceed to emerge by way of the quick improvement of recent healing brokers to be investigated in medical trials. Optimizing the healing power of antiangiogenic brokers together with the opposite treatments within the armamentarium to struggle melanoma could be an on-going challenge.

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Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res 2006;66:8065–8075. 108. Fujisawa H, Kitsukawa T. Receptors for collapsin/semaphorins. Curr Opin Neurobiol 1998;8: 587–592. 109. Ellis LM. The role of neuropilins in cancer. Mol Cancer Ther 2006;5:1099–1107. 22 Part I / Basic Biology of Angiogenesis 110. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M.

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Hassan I, Wunderlich A, Slater E, Hoffmann S, Celik I, Zielke A. Antisense p53 decreases production of VEGF in follicular thyroid cancer cells. Endocrine 2006;29:409–412. 178. Pal S, Datta K, Mukhopadhyay D. Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res 2001;61:6952–6957. 179. Bouvet M, Ellis LM, Nishizaki M, et al. Adenovirus-mediated wild-type p53 gene transfer downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.

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