Antiphospholipid Antibody Syndrome: From Bench to Bedside by Pier Luigi Meroni

By Pier Luigi Meroni

This booklet, a part of the sequence infrequent illnesses of the Immune method, deals complete, up to date insurance of the pathophysiology and administration of the antiphospholipid syndrome (APS). Immunologic and genetic features are mentioned and the pathogenic mechanisms liable for such phenomena as APS-mediated thrombosis and being pregnant loss/complications are defined. the most medical manifestations, type standards and diagnostic instruments are pointed out, and shut realization is paid to the character of the involvement of assorted organs or organ platforms in APS. particular chapters describe the remedy of the various signs, treatments of worth in fending off recurrences, and cutting edge therapy methods. The authors are senior specialists within the box who're aided via more youthful fellows, making sure that the booklet can be educationally orientated. this useful quantity should be a precious software for postgraduates in education and pros wishing to increase their wisdom of this particular syndrome.

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Extra info for Antiphospholipid Antibody Syndrome: From Bench to Bedside (Rare Diseases of the Immune System)

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J Lab Clin Med 62:416–430 7. Jayakody Arachchillage D, Greaves M (2014) The chequered history of the antiphospholipid syndrome. Br J Haematol 165:609–617 8. Exner T, Rickard KA, Kronenberg H (1975) Studies on phospholipids in the action of a lupus coagulation inhibitor. Pathology 7:319–328 9. Manoharan A, Gibson L, Rush B, Feery BJ (1977) Recurrent venous thrombosis with a “lupus” coagulation inhibitor in the absence of systemic lupus. Aust N Z J Med 7:422–426 10. Harris EN, Gharavi AE, Boey ML et al (1983) Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus.

6 % according to screening using the KCT, but it may be much less. The prevalence of LAC in the SLE population has been reported to be between 10 and 50 %, depending on the test used [35]. 2 The Paradox of Lupus Anticoagulant 21 The lupus anticoagulant is detected according to a set of diagnostic criteria recommended by the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. The sensitivity and specificity of these procedures vary, depending on the type of test, reagents, instrumentation, cutoff values, and the expression of results utilized.

Iverson GM et al (1998) Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β 2GPI. Proc Natl Acad Sci U S A 95:15542–15546 13. McNeely PA et al (2001) β 2-glycoprotein I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of β 2-glycoprotein I. Thromb Haemost 86:590–595 14. Iverson GM et al (2002) Use of single point mutations in domain I of β2-glycoprotein I to determine fine antibody specificity of antiphospholipid autoantibodies.

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